{"product_id":"retinoids-in-development-and-disease-volume-161-9780323917001","title":"Retinoids in Development and Disease: Volume 161","description":"\u003ci\u003eRetinoids in Development and Disease, Volume 161 \u003c\/i\u003ein the \u003ci\u003eCurrent Topics in Developmental Biology\u003c\/i\u003e series focuses on the role of retinoids during development and disease. Topics covered include Retinoids, Retinol-Binding Protein 2 (RBP2), Retinol-Binding Protein 4 (RBP4): Obesity and Metabolic Disease, Early Retinoic Acid Signaling Organizes the Body Axis and Defines Domains for the Forelimb and Eye, Rethinking Retinoic Acid Self-Regulation: A Signaling Robustness Network Approach, Meiotic initiation in the fetal ovary without retinoic acid receptors: an unforeseen twist, Action of retinoic acid on progenitor cells in the testis, amongst many other topics. \u003cp\u003e\u003c\/p\u003eAdditional sections cover Retinoic acid homeostasis and disease, Redefining the roles of endogenously produced retinoic acid in heart development and regeneration: lessons from genetic models, The Multifaceted Roles of Retinoids in Vision, Eye Development, and Retinal Degenerative Diseases, Essential roles for retinoid signaling in craniofacial development, and much more.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAbout the Author\u003c\/b\u003e\u003cbr\u003e\u003cb\u003e\u003ci\u003eGhyselinck, Norbert:\u003c\/i\u003e\u003c\/b\u003e - The goal of my research is to understand the function of all-\u003ci\u003etrans\u003c\/i\u003e retinoic acid (ATRA) receptors (RARs) during development and in germ cell physiology. Early in my career I gained a background in reproductive biology with expertise in the area of nuclear receptor signaling. This inspired my research direction. As a postdoctoral fellow in the group of Pr Pierre CHAMBON, I generated and analyzed mutant mice lacking the beta isotype of RAR. Obtaining a permanent position of researcher at the French CNRS (Centre National de la Recherche Scientifique) in 1998, my research led to the characterization of a large panel of RAR-deprived mutant models, yielding the first evidence that (i) RXR\/RAR heterodimers are transducers of the ATRA signal in vivo, (ii) specific heterodimers are required at many distinct stages during early embryogenesis and organogenesis, (iii) the physiological role of ATRA and its nuclear receptors cannot be extrapolated from teratogenesis studies using retinoids in excess. In 2001, I founded my own research team at Institut de G?n?tique et Biologie Mol?culaire et Cellulaire (IGBMC), and expanded my research into the function of ATRA synthesizing enzymes during development. Later, by studying spatiotemporally loss-of-function genetic mouse models, I investigated the role of RARs in gametogenesis. As a PI on several ANR-funded grants, I showed that ATRA-activated RARs acting both in spermatogonia and in supporting, Sertoli, cells of the seminiferous epithelium are necessary to induce spermatogonia differentiation. I also provided genetic evidence that RARs (as well as ATRA-synthesizing enzymes) are fully dispensable for meiotic initiation in both oocytes and spermatocytes, disqualifying thereby ATRA act as the long-searched meiosis-inducing substance. I was an author on several reviews including a 2006 article in \u003ci\u003eAnnual Reviews in Pharmacology and Toxicology \u003c\/i\u003esummarizing the function of RAR during mouse embryogenesis and organogenesis. In 2015 and 2017, my laboratory published two reviews in \u003ci\u003eBiochimica et Biophysica Acta\u003c\/i\u003e and in \u003ci\u003eCurrent Topics in Developmental Biology\u003c\/i\u003e summarizing the knowledge on the function of ATRA-activated RARs in germ cell differentiation gained by studying loss-of-function mouse models. In 2019, I published a Development at A Glance review on ATRA signaling in \u003ci\u003eDevelopment\u003c\/i\u003e along with Pr. Duester who is a co-Editor in this volume of \u003ci\u003eCurrent Topics in Developmental Biology\u003c\/i\u003e. As Pr. Duester, my goal now is to bring knowledge of how ATRA normally functions to as wide an audience as possible.\u003cb\u003e\u003ci\u003eDuester, Gregg:\u003c\/i\u003e\u003c\/b\u003e - \u003cp\u003eThe goal of my research is to understand the function of retinoic acid (RA) during development. Early in my career I gained a broad background in developmental biology with expertise in the area of RA signaling that directed my research direction. As a postdoctoral fellow I cloned one of the first genes known to encode an enzyme for RA synthesis. As an Assistant Professor my research led to the discovery and characterization of one of the first RA response elements to be described. As a Professor at the Sanford Burnham Prebys (SBP) Medical Discovery Institute, I expanded my research into the function of RA by generating mouse knockouts of enzymes controlling RA synthesis. As a PI on several NIH-funded grants, I laid the groundwork for understanding RA function by providing genetic loss-of-function evidence implicating RA in major developmental pathways including eye development, body axis formation, somitogenesis, limb formation, and neurogenesis. I was an author on several reviews including a 2008 article in \u003ci\u003eCell\u003c\/i\u003e summarizing what is known about embryonic RA synthesis and signaling, and a \u003ci\u003eCell\u003c\/i\u003e SnapShot on Retinoic Acid Signaling in 2011. In 2015, my laboratory published a review in \u003ci\u003eNature Reviews Molecular Cell Biology\u003c\/i\u003e summarizing the developmental pathways and genes directly controlled by RA during organogenesis. In 2017, I published a Letter in \u003ci\u003eScience\u003c\/i\u003e describing how challenges in the RA signaling field can be solved with more reliance on knockout studies which can now be performed more easily with CRISPR\/Cas9 gene editing. In 2019, I published a Development at A Glance review on RA signaling in \u003ci\u003eDevelopment\u003c\/i\u003e along with Dr. Ghyselinck who is a co-Editor in this volume of \u003ci\u003eCurrent Topics in Development and Disease\u003c\/i\u003e. My goal now is to bring knowledge of how RA normally functions to as wide an audience as possible.\u003c\/p\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":51298562998546,"sku":"9780323917001","price":230.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0831\/4771\/8930\/files\/img_ea816d67-0039-4ff9-8eae-178804a733cc.jpg?v=1747827475","url":"https:\/\/surprise-castle.myshopify.com\/products\/retinoids-in-development-and-disease-volume-161-9780323917001","provider":"Surprise Castle","version":"1.0","type":"link"}