{"product_id":"mitosis-9781621821359","title":"Mitosis","description":"Virtually every cell in a living organism contains an identical set of chromosomes thanks to mitosis, a complex process involving hundreds of proteins and regulatory steps that ensures duplicated chromosomes are segregated equally into each daughter cell when a cell divides. Errors in this process can lead to genomic instability and are associated with cancer and other diseases. \u003cp\u003e\u003c\/p\u003eWritten and edited by experts in the field, this collection from \u003cem\u003eCold Spring Harbor Perspectives in Biology \u003c\/em\u003ecovers both historical and recent developments in our understanding of mitosis and its regulation. The contributors describe how sister chromatids attach to one another and to the spindle apparatus; how the spindle microtubules nucleate, elongate, pause, and shrink; and how kinetochores and centrosomes serve as anchor and control points. They also survey the biochemical machinery that coordinates the three main regulatory stages-entry into mitosis, sister chromatid separation, and mitotic exit-in both space and time. \u003cp\u003e\u003c\/p\u003eThe cellular changes that occur during cytokinesis are also reviewed in detail, as are the key differences between mitosis and meiosis. This volume will serve as a valuable reference for all cell and molecular biologists interested in this dramatic phase of the cell cycle.\u003cbr\u003e","brand":"Cold Spring Harbor Laboratory Press","offers":[{"title":"Default Title","offer_id":50856120156434,"sku":"9781621821359","price":15.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0831\/4771\/8930\/files\/img_e3570842-2b39-4fd7-817d-1186656a7281.jpg?v=1737496207","url":"https:\/\/surprise-castle.myshopify.com\/products\/mitosis-9781621821359","provider":"Surprise Castle","version":"1.0","type":"link"}