{"product_id":"antibodies-and-their-role-in-therapeutics-9789355781604","title":"Antibodies and their role in therapeutics","description":"\u003cp\u003eBeginning with the structure, types, functions, and gene organization of antibodies, the book aims to shine a detailed light on \u003cstrong\u003ethe monoclonal antibodies (often referred to as mAbs)\u003c\/strong\u003e that have revolutionized the fields of therapeutics and diagnostics.\u003c\/p\u003e\u003cp\u003eThe book describes the different ways of generating \u003cstrong\u003echimeric, humanized, and fully human monoclonal antibodies, \u003c\/strong\u003eemphasizing phage display, hybridoma, and rDNA technology. In addition, the book focuses on the various recombinant antibody formats in detail: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eDrug conjugates: Antibody-drug conjugates (ADCs), Immunotoxins (Recombinant, Humanized and Fully Human) and Antibody-antibiotic conjugate (AAC)\u003c\/li\u003e\n\u003cli\u003eBispecific antibodies: scFv based (BiTE, DARTs and TandAbs) and Full-length IgG based\u003c\/li\u003e\n\u003cli\u003eAbzymes and Antibody-directed enzyme prodrug therapy (ADEPT)\u003c\/li\u003e\n\u003cli\u003eFc-fusion proteins\u003c\/li\u003e\n\u003cli\u003eSingle-domain antibodies (VHH and IgNAR sdAb)\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eThe book discusses the various therapeutic applications of monoclonal antibodies, along with the immunogenicity issues. The book also covers the modes of administration and side effects of monoclonal antibodies, along with the challenges and issues faced while developing a monoclonal antibody into a therapeutic agent. Modifications introduced by the researchers to decrease the immunogenicity issues and increase the efficacy of therapeutic mAbs are also described.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eThe book is an invaluable resource for researchers and students in biology and medicine, biotechnology, immunology, genetics, molecular biology, and anyone interested in antibody engineering.\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e","brand":"Roohi Bansal","offers":[{"title":"Default Title","offer_id":50486027157778,"sku":"9789355781604","price":25.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0831\/4771\/8930\/files\/img_a3518d6c-525a-4c2a-945c-d27947e2b10a.jpg?v=1730418138","url":"https:\/\/surprise-castle.myshopify.com\/products\/antibodies-and-their-role-in-therapeutics-9789355781604","provider":"Surprise Castle","version":"1.0","type":"link"}