{"product_id":"a-guide-to-sample-size-for-animal-based-studies-9781119799979","title":"A Guide to Sample Size for Animal-Based Studies","description":"\u003cb\u003eA Guide to Sample Size for Animal-based Studies\u003c\/b\u003e \u003cp\u003e\u003cb\u003eUnderstand a foundational area of experimental design with this innovative reference\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eAnimal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs - Replacement, Reduction and Refinement - the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eA Guide to Sample Size for Animal-based Studies\u003c\/i\u003e meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to \"rightsizing\" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. \u003c\/p\u003e\u003cp\u003eThis book offers: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eStep-by-step guidance in diverse methods for approximating and refining sample size\u003c\/li\u003e \u003cli\u003eDetailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies\u003c\/li\u003e \u003cli\u003eSample size approximation methods for different types of data - binary, continuous, ordinal, time to event - and different study types - description, comparison, nested designs, reference interval construction and dose-response studies\u003c\/li\u003e \u003cli\u003eNumerous worked examples, using real data from published papers, together with SAS and R code\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eA Guide to Sample Size for Animal-based Studies\u003c\/i\u003e is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAbout the Author\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePenny S. Reynolds, PhD, \u003c\/b\u003e is a Research Assistant Professor in the Department of Anesthesiology, College of Medicine, and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, USA.\u003cbr\u003e\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":50398377115922,"sku":"9781119799979","price":66.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0831\/4771\/8930\/files\/img_0acda27d-30f7-47a6-aa86-254f4a3a91d9.jpg?v=1729066647","url":"https:\/\/surprise-castle.myshopify.com\/products\/a-guide-to-sample-size-for-animal-based-studies-9781119799979","provider":"Surprise Castle","version":"1.0","type":"link"}